Iron regulation by hepatocytes and free radicals
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چکیده
منابع مشابه
Iron regulation by hepatocytes and free radicals
Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferropor...
متن کاملIron, free radicals, and oxidative injury.
Iron metabolism and superoxide metabolism are clearly interactive, especially under pathological conditions. Each can exacerbate the toxicity of the other. Iron overload may amplify the damaging effects of superoxide overproduction in a very broad spectrum of inflammatory or ischemia-related conditions. Furthermore, chronic oxidative stress may modulate iron uptake and storage, leading to a sel...
متن کاملStimulation of microsomal lipid peroxidation by iron and cysteine. Characterization and the role of free radicals.
The stimulation of microsomal lipid peroxidation by FeSO4 and cysteine has been investigated. Although both FeSO4 and cysteine alone promoted an increase in malonaldehyde production, when these agents were added together to microsomes the resultant level of malonaldehyde was greater than the sum of the amounts formed by these pro-oxidants when acting individually. A further indication of an int...
متن کاملFree Radicals in Surviving Tissues* By
7Kearney, E. B., T. P. Singer, and N. Zastrow, Arch. Biochem. Biophys., 55, 579 (1955). 8 Singer, T. P., and E. B. Kearney, Biochim. Biophys. Acta, 15, 151 (1954). 9 Singer, T. P., E. B. Kearney, and V. Massey, Adv. Enzymol., 18, 65 (1957). 10 Singer, T. P., E. B. Kearney, and N. Zastrow, Biochim. Biophys. Acta, 17, 154 (1955). " Singer, T. P., and E. B. Kearney, in Methods of Biochemical Analy...
متن کاملThe labile iron pool in hepatocytes: prooxidant-induced increase in free iron precedes oxidative cell injury.
The labile iron pool (LIP) represents the nonferritin-bound, redox-active iron that has been implicated in oxidative stress and cell injury. Here we examined whether alterations in LIP can be detected in cultured murine hepatocytes and whether increases in LIP are related to the oxidative damage inflicted by the redox cycling drug nitrofurantoin (NFT). Early changes in LIP were monitored with t...
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ژورنال
عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition
سال: 2011
ISSN: 1880-5086,0912-0009
DOI: 10.3164/jcbn.10-76